There currently are a variety of options to travel by night train or night bus from Prague (Czech Republic) to Brussels (Belgium), taking between approximately 12 and 18 hours: Namely the ES 452 and the BUS Praha - Londýn. These lines are operated by European Sleeper and Regiojet.

Next offers

European Sleeper is a young Dutch startup connecting several European cities in Belgium, the Netherlands, Germany and the Czech Republic with their "Good Night Train". The sleeper cars offer comfortable and lockable compartments for one, two or three persons, each equipped with a washbasin. The service includes bedding, towels, toiletries and breakfast. A wake-up service is available. The couchette cars come in two variants: standard (6 people) and comfort (5 people, air-conditioned). Both include bedding, blankets and pillows. Comfort compartments can be booked as private or women-only compartments. The compartments can be locked from the inside. As the most economical option, seating cars with 6-person compartments are available. Seat reservations are included in the price. Drinks and snacks can be purchased from the train crew.

Regiojet operates both night trains and night buses across Europe, providing various travel options. Their night trains feature several types of cabins, including seats that can recline slightly for added comfort, as well as private sleeping couchettes that accommodate one to four passengers, equipped with bedding and duvets. Wifi is available and breakfast and coffee are complimentary. The night buses are designed with comfortable, spacious seats that recline, providing ample legroom. Each bus is equipped with individual power outlets, free hot drings, free WiFi, and onboard entertainment systems to enhance the travel experience. Buses also feature a toilet.

For the next 7 dates with connections, the cheapest offer starts at 40 EUR. Check our connection pages below for all availabilities!

Next available offers

Fri, 09.05.2025

from 50 EUR

Sun, 11.05.2025

from 150 EUR

Tue, 13.05.2025

from 40 EUR

Thu, 15.05.2025

from 60 EUR

Fri, 16.05.2025

from 40 EUR

Sun, 18.05.2025

from 90 EUR

Tue, 20.05.2025

from 40 EUR